RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
CTHRC1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
Cell Culture; Microarray Statistical Data Analysis; Gene Expression Analysis
Target
NA
Pathway
NA
PubMed ID
Title
A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis
Year
2015
Function
"Cthrc1 is expressed by fibroblasts, is involved in vascular remodeling, and decreases collagen matrix deposition . Cthrc1 is a downstream target of bone morphogenic protein-SMAD signaling, inhibits TGF-beta expression in neointimal lesion formation, and acts as a Wnt cofactor, possibly contributing to the promotion of cell motility. "